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Summary
After eating sweets, the brain releases opioids, which are responsible for a feeling of intense pleasure. The brain recognises the feeling and begins to crave it. When one craves sugar, certain are in the brain - the hippocampus, the insula and the caudate - are activated. There is also evidence that the very same areas are activated in brains of drug addicts when they crave drugs.
Mycroft Holmes knew and understood all of this perfectly well.
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